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pentobarbital will reduce the extent or result of estradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers could boost the metabolism of ifosfamide to its Energetic alkylating